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| 04:00 Instituto Atletico Central Cordoba – Platense 2:1 | 2.08 | 2.91 | 4.38 | 1X | 1-0 | U |
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| 04:00 EC Vitoria Salvador – Sociedade Esportiva Palmeiras 0:4 | 4.16 | 3.12 | 2.08 | X2 | 0-1 | U |
| 04:00 Fluminense – Bahia 0:0 | 1.73 | 3.74 | 5.09 | X2 | 1-2 | O |
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| 17:30 Atletic d'Escaldes – Vaduz 0:2 | 5.48 | 4.09 | 1.63 | 2 | 1-2 | O |
| 17:30 Tobol Kostanay – Panevezys 1:1 | 1.28 | 5.83 | 11.60 | 1 | 2-1 | O |
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| 19:00 JIPPO – JaPS 1:0 | 1.43 | 4.15 | 6.28 | X2 | 1-2 | O |
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| 19:30 Auda – FCSB 4:1 | 4.92 | 4.24 | 1.66 | 2 | 1-2 | U |
| 19:30 Ilves – Stjarnan 3:1 | 1.73 | 3.98 | 4.71 | 1 | 2-1 | O |
| 19:30 Inter Turku – Istanbul BFK 2:0 | 5.54 | 3.99 | 1.64 | 2 | 1-2 | U |
| 19:30 Jablonec – NK Varazdin 2:0 | 1.72 | 3.93 | 4.81 | X2 | 1-2 | O |
| 19:30 Noah Yerevan – Zimbru Chisinau 2:1 | 1.31 | 5.54 | 10.30 | 1 | 2-1 | O |
| 19:30 Nomme Kalju – Shelbourne 2:1 | 3.44 | 3.52 | 2.14 | X2 | 1-2 | U |
| 19:30 Pyunik – Debreceni VSC 0:0 | 2.16 | 3.30 | 3.64 | 1X | 1-0 | U |
| 19:30 Zira – Paide Linnameeskond 1:1 | 1.20 | 6.65 | 16.00 | X2 | 1-2 | O |
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| 19:30 Maccabi Tel Aviv – Sheriff Tiraspol 1:0 | 1.37 | 5.08 | 8.80 | X2 | 1-2 | U |
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| 20:00 Levadia – Goteborg 0:2 | 3.27 | 3.70 | 2.14 | 1X | 2-1 | O |
| 20:30 Brann – Universitatea Cluj 3:1 | 1.43 | 4.79 | 7.60 | 1 | 3-0 | U |
| 20:30 Havnar Boltfelag – Motherwell 0:3 | 6.10 | 4.12 | 1.57 | 2 | 1-2 | O |
| 20:30 Nordsjaelland – GAIS 6:0 | 1.53 | 4.35 | 6.26 | X2 | 1-2 | O |
| 20:30 Dinamo Minsk – Neftchi Baku 0:1 | 2.98 | 3.37 | 2.50 | X2 | 0-1 | U |
| 20:30 Gyori ETO – Atert Bissen 1:1 | 1.21 | 7.05 | 13.80 | 1 | 3-0 | O |
| 20:30 Petrocub – Borac Banja Luka 3:3 | 3.94 | 3.54 | 1.98 | 2 | 1-2 | U |
| 20:30 Velez Mostar – DAC 1904 0:3 | 4.00 | 3.46 | 1.99 | 2 | 1-2 | O |
| 20:30 VMFD Zalgiris Vilnius – Dinamo Tbilisi 7:2 | 1.98 | 3.73 | 3.73 | X2 | 0-1 | U |
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| 20:30 Hradec Kralove – Tromso 3:1 | 3.17 | 3.66 | 2.20 | 2 | 1-2 | U |
| 20:30 Midtjylland – Besiktas 0:2 | 1.96 | 3.81 | 3.72 | X2 | 1-2 | U |
| 20:30 Pafos – Hajduk Split 4:0 | 1.77 | 3.95 | 4.46 | 1 | 2-1 | O |
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| 21:00 Beitar Jerusalem – AEK Larnaca 3:3 | 2.05 | 3.54 | 3.68 | 1X | 1-0 | U |
| 21:00 Valletta – Rakow Czestochowa 0:4 | 5.90 | 4.30 | 1.56 | 2 | 1-2 | U |
| 21:00 Derry City – Rijeka 0:1 | 5.48 | 3.83 | 1.67 | 2 | 1-2 | O |
| 21:00 The New Saints – Flora Tallinn 1:1 | 1.94 | 3.68 | 3.94 | X2 | 1-2 | O |
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| 21:15 P.A.O.K. – Dynamo Kyiv 2:0 | 1.80 | 3.80 | 4.46 | 1 | 2-1 | U |
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| 21:30 Ludogorets 1945 – Hapoel Tel Aviv 2:2 | 1.76 | 4.02 | 4.45 | X2 | 1-2 | O |
| 21:30 Ajax – Vojvodina Novi Sad 4:1 | 1.16 | 8.15 | 16.50 | 1 | 2-1 | O |
| 21:30 Ballkani – Bohemian Dublin 3:2 | 2.38 | 3.50 | 2.98 | X2 | 1-2 | U |
| 21:30 Skendija – NK Bravo 3:1 | 1.60 | 4.14 | 5.75 | 1 | 2-1 | U |
| 21:30 Vestri – Rigas Futbola skola 1:1 | 12.90 | 6.58 | 1.23 | 2 | 1-2 | O |
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| 21:30 CSKA Sofia – Qarabag 1:0 | 2.57 | 3.34 | 2.82 | X2 | 1-2 | O |
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| 21:45 Sion – BATE Borisov 4:0 | 1.10 | 11.40 | 21.00 | X2 | 1-2 | O |
| 21:45 UNA Strassen – Partizan Belgrade 0:1 | 4.97 | 3.98 | 1.70 | 2 | 1-2 | U |
| 22:00 CFR Cluj – Alashkert 3:0 | 1.54 | 4.24 | 6.31 | X2 | 1-2 | O |
| 22:00 Panathinaikos – Paksi 2:2 | 1.28 | 5.83 | 11.60 | X2 | 1-2 | O |
| 22:00 Austria Wien – Liepaja 3:1 | 1.28 | 5.97 | 11.10 | X2 | 1-2 | O |
| 22:00 Gent – LNZ 1:0 | 1.52 | 4.04 | 7.25 | 1 | 2-1 | O |
| 22:00 Katowice – MSK Zilina 3:1 | 1.65 | 4.06 | 5.33 | X2 | 1-2 | U |
| 22:00 Zrinjski – Valur 2:2 | 1.23 | 6.50 | 13.20 | X2 | 1-2 | O |
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| 22:00 Anderlecht – Hammarby 3:1 | 2.15 | 3.60 | 3.34 | X2 | 0-1 | U |
| 22:00 Ferencvarosi – Twente 2:2 | 2.90 | 3.91 | 2.32 | 1X | 2-1 | U |
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| 22:15 Coleraine – HJK 0:3 | 4.08 | 4.02 | 1.82 | 2 | 1-2 | O |
| 22:15 Koper – NSI Runavik 1:4 | 1.45 | 4.90 | 6.82 | 1 | 2-1 | O |
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| 22:30 Club Sportivo San Lorenzo – Club Guarani 0:1 | 3.62 | 2.90 | 2.23 | 1X | 2-1 | U |
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| 22:30 Dinamo City – NK Aluminij 3:0 | 1.77 | 3.68 | 4.87 | 1 | 2-1 | O |
| 22:30 Hibernian – Malisheva 4:1 | 1.23 | 6.56 | 12.90 | X2 | 1-2 | O |
| 22:30 Sutjeska Niksic – ML Vitebsk 1:2 | 2.88 | 3.47 | 2.46 | X2 | 1-2 | U |
| 22:30 Braga – Zeleznicar Pancevo 4:0 | 1.14 | 8.45 | 23.00 | 1 | 2-1 | O |
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| 22:30 Benfica – St. Gallen 5:0 | 1.13 | 9.60 | 20.00 | X2 | 1-2 | O |
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| 01:00 Club Libertad – Deportivo Recoleta 4:1 | 1.83 | 3.46 | 4.24 | 1 | 2-1 | O |
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| 01:30 Independiente Rivadavia – Club Atletico Huracan 2:1 | 2.22 | 2.95 | 3.79 | X2 | 1-2 | U |
| 01:30 Talleres de Cordoba – Velez Sarsfield 1:3 | 2.58 | 2.80 | 3.26 | X2 | 1-2 | U |
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| 02:00 Corinthians Paulista – Clube Atletico Paranaense 0:0 | 1.95 | 3.29 | 4.46 | X2 | 1-2 | U |
